Search results for "HIV-1 Rev"

showing 2 items of 2 documents

Computational methodologies in the discovery of inhibitors of HIV-1

2009

HIV-1 reverse trascriptaseHIV-1 proteasedockingpharmacophore modelingmultivariate analysiSettore CHIM/08 - Chimica FarmaceuticaHIV-1 inhibitor
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Translocation Biosensors – Cellular System Integrators to Dissect CRM1-Dependent Nuclear Export by Chemicogenomics

2009

Fluorescent protein biosensors are powerful cellular systems biology tools for dissecting the complexity of cellular processes with high spatial and temporal resolution. As regulated nucleo-cytoplasmic transport is crucial for the modulation of numerous (patho)physiological cellular responses, a detailed understanding of its molecular mechanism would open up novel options for a rational manipulation of the cell. In contrast to genetic approaches, we here established and employed high-content cellular translocation biosensors applicable for dissecting nuclear export by chemicogenomics. A431 cell lines, stably expressing a translocation biosensor composed of glutathione S-transferase, GFP and…

Systems biologyChemical biologyNanotechnologychemical biologyComputational biologyBiologylcsh:Chemical technologyBiochemistryArticleAnalytical ChemistryGreen fluorescent proteinFlow cytometrychemical biology; cancer; Exportin 1/CRM1; HIV-1 Rev; import; LMB; nucleocytoplasmic transport; nucleoporinimportmedicinecancerlcsh:TP1-1185Electrical and Electronic EngineeringNuclear export signalLMBInstrumentationExportin 1/CRM1HIV-1 Revnucleocytoplasmic transportmedicine.diagnostic_testnucleoporinAtomic and Molecular Physics and OpticsChemical spacecancer ; HIV-1 Rev ; import ; nucleocytoplasmic transport ; LMB ; chemical biology ; Exportin 1/CRM1 ; nucleoporinNucleoporinNuclear transportBiologieSensors
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